Skin-aging is increasingly seen as a sign of deep biological imbalance. Gattefossé and Ambiotis are exploring the role of pro-resolving lipids in skin health. The collaboration paves the way for innovative cosmetic solutions focused on a more integrative approach to aging, according to the companies.

The clinical signs of aged skin are well documented, but skin aging remains a largely misunderstood process. Gattefossé and Ambiotis are studying the role of pro-resolving lipids found in the secretome, in interaction with macrophages and fibroblasts.

Gattefossé and Ambiotis characterized and modeled the alterations of pro-resolving lipids observed in aged skin. These changes disrupt the interactions between macrophages and dermal fibroblasts. As a result, dermal fibroblasts become abnormally activated. They adopt a pro-inflammatory and pro-degradative phenotype marked by increased secretion of matrix metalloproteinases.

Researchers say these lipids play a key role in enabling the body to move from a state of imbalance to a restored state of equilibrium.

More info: Gattefosse, www.gattefosse.com